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Vancouver Back Pain Related to Inflammation Reduced with Melatonin

Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it tries to repair itself before the harm was done. Vancouver Disc Centers is never shocked at what the body can do! Vancouver Disc Centers sees its Vancouver chiropractic care as the body’s partner in healing especially when there is spine pain. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is showing value in its ability to interrupt the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.

DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'

Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to the cellular level via autophagy, the natural process via which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin enhanced autophagy and decreased the degradation of the disc’s extracellular matrix (technically indicated by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Vancouver Disc Centers is encouraged by this research to see just how well melatonin can perform for Vancouver back pain linked to disc degeneration.

MELATONIN AND ITS HEALING WAYS FOR THE DISC

Disc degeneration is a very common malady seen at Vancouver Disc Centers making positive news like this quite rousing. A recent study described that melatonin could modify the extracellular matrix of the disc remodeling process started by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and decreased the release of linked inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin interrupted the IL-1B feedback loop, researchers proposed that melatonin may support the restoration process of intervertebral discs after damage has already been done. (1) Vancouver Disc Centers continues following the new research regarding the role inflammation plays in Vancouver disc degeneration and melatonin’s role in combatting it.

INFLAMMATION AND MELATONIN

The significance of melatonin in assisting to slow or stop painful conditions due to inflammation is growing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite appropriate. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin influences the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific influence on inflammation and disc degeneration is most attention-getting to Vancouver Disc Centers and our Vancouver back pain patients.

CONTACT Vancouver Disc Centers

Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she illustrates how The Cox® Technic System of Spinal Pain Management handles disc degeneration for relief of chronic low back pain in her patient.

Schedule your Vancouver chiropractic appointment with Vancouver Disc Centers soon. We can talk about how inflammation affects your back pain and how melatonin may help with the related disc degeneration.

 
Vancouver Disc Centers presents new findings that melatonin interrupts the inflammatory process in disc degeneration that causes back pain. 
 
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"This information and website content is not intended to diagnose, guarantee results, or recommend specific treatment or activity. It is designed to educate and inform only. Please consult your physician for a thorough examination leading to a diagnosis and well-planned treatment strategy. See more details on the DISCLAIMER page. Content is reviewed by Dr. James M. Cox I."